Song Thanh National Park is divided into 2 areas: a 93,429 hectare (230868 acre) core zone; and a 108,398 hectare (267857 acres) buffer zone. The core zone is divided into two areas: a preservation-only area of 75,373 hectares and an ecological rehabilitating area of 17,512 hectares.
The Thanh River Nature Reserve has 830 species of higher plants, which were recorded through surveys in 1997 and 1999 by WWF - Indochina and the Vietnam Forest Inventory and Planning Institute. Among them, there are 23 useful species, of which 38 species are listed in the Red Book of Vietnam. The forest fauna of this reserve is also very diverse with a list of 53 species of mammals, 183 species of birds, 33 species of reptiles, 21 species of amphibians, 25 species of fish... and many other large and rare mammals such as tigers, leopards, elephants, brown-shanked langurs, gray-shanked langurs, and Truong Son gills.